Quality of bladder cancer treatment information on YouTube: May the user's profile affect the quality of results?

BACKGROUND: Social media are widely used information tools, including the medical/health field. Unfortunately, the levels of misinformation on these platforms seem to be high, with a medium-low quality of the proposed content, as evidenced by previous studies. You Tube is one of the most important platforms for audio/video content. It shows content to users through a recommendation algorithm system. MATERIALS AND METHODS: We have classified in two cohorts the first results obtained by researching "bladder tumor treatment" on You Tube through two different user profiles: "Cohort A" with a not logged-in session in incognito mode (46 videos enrolled) and "Cohort B" with a logged-in session with a physician profile (50 videos enrolled). The videos were evaluated using validated instruments such as DISCERN and PEMAT-AV Furthermore, we used a Likert's scale for the evaluation of levels of misinformation. RESULTS: Overall quality of information was moderate to poor (DISCERN 3) in 54% of Cohort A and 24% of Cohort B. Moreover, a high degree of misinformation (Likert score 3) was found in 52% of Cohort A cases and 32% of Cohort B. CONCLUSIONS: Levels of misinformation in both cohorts are positively correlated to the number of views per month. Globally, the levels of information quality, understandability and actionability are lower for the results obtained from searches performed with anonymous user profile (Cohort A).

Early diagnosis and management of arterio-ureteral fistulas: A literature review.

OBJECTIVES: Arterio-ureteralfistula (AUF) is an infrequent but potentially life-threatening condition. The aim of this study was reviewing the literature to build a flow-chart useful for an early and effective diagnosis and treatment of this pathology. MATERIALS AND METHODS: A literature search in PubMed was conducted. In addition, retrieved articles were cross-referenced. Data parameters included oncologic, vascular and urological history, diagnostics, treatment, and follow up were collected using a standard template by 2 independent reviewers. RESULTS: A total of 140 cases of AUF out of 172 available in the literature at the time of the review, were considered. All patients presented gross hematuria. Chronic indwelling ureteral catheter (CIUC); history of pelvic surgery (HPS) and history of pelvic radiotherapy (HRT) were present respectively in 81%, 62.1%and 58.6% of the sample. The most predominant location of AUF was at the common iliac artery ureteral crossing. Angiography with provocative measures had the highest diagnostic sensitivity (50%) and endovascular treatment with stent-graft placement across the fistula is the current state of the art treatment choice. CONCLUSIONS: Failure to diagnose can postpone a potentially life-saving targeted therapy and lead to complications. The identifi-cation of the Trifecta hematuria, history of pelvic surgery (HPS) and history of pelvic radiotherapy (HPR) would allow the identity-fication of patients at high risk of AUF, who may benefit from more sensitive early diagnostic investigations such as CT angiography and provocative angiography. The treatment of choice in case of AUF to date consist in endovascular prosthesis placement.

Transurethral water vapor ablation of the prostate with the Rezum system: Urodynamic findings.

AIMS: The efficacy of the transurethral convective interstitial radiofrequency water vapor thermal ablation of the prostate with the Rezum system for the treatment of male lower urinary tract symptom due to benign prostatic hyperplasia is well proven. The improvement of urodynamic parameters obtained from a simple uroflowmetry cannot measure the effect of water vapor injection on the bladder outlet obstruction. METHODS: This monocentric retrospective pilot study analyzes the data of pressure-flow studies performed before and after 17 Rezum procedures to answer the question whether thus obtained ablation of prostate tissue has a disobstructive effect on the bladder outlet. RESULTS: All the functional outcomes were consistently improved after the procedure, with a median flowrate increase of 5.1 ml/s (p = 0.0022) and a median postvoid residual urine (PVR) reduction of 100 ml (p = 0.0042). The prostate volume was reduced by 40% (p < 0.0001) and the median Bladder Outlet Obstruction Index (BOOI) reduction was 53.8 (p < 0.0001). CONCLUSIONS: These data show that the possibility to significantly reduce the obstruction grade with even a single Rezum procedure is concrete and seems to be independent from the degree of the obstruction grade.

Oncological and functional outcomes of extraperitoneal laparoscopic radical prostatectomy: An 18-years, single-center experience.

OBJECTIVE: To present a retrospective analysis on the oncological and functional outcomes of a single-center experience on a large series of extraperitoneal laparoscopic radical prostatectomies (eLRP) with an extended follow-up. MATERIALS AND METHODS: Herein we present a retrospective review of patients who underwent eLRP. Oncological and functional follow-up data were collected by means of outpatient visits and telephone interviews, assessing overall mortality and biochemical recurrence-free survival. Patients with clinical T4 stage prostate cancer (PCa), previous surgery for benign prostatic hyperplasia (BPH), previous androgen deprivation, radiotherapy, concomitant chemotherapy and/or experimental therapies, and with insufficient follow-up data were excluded. Preoperative data recorded were age, body mass index, ultrasound prostate volume, preoperative PSA and clinical stage of PCa. Operative data (operative time, nerve sparing technique and any perioperative complication) and pathological findings were obtained by consulting the surgical and pathological reports. Oncological and functional follow-up were collected during follow-up visits and telephone interview. RESULTS: Between January 2001 and December 2019, overall 938 eLRP were performed at our Institution. The median follow-up was 132 months. 69.7% of the patients had complete dataset. The estimated overall biochemical recurrence (BCR)-free survival was 71.4% at 5 years and 58.9% at 10 years. Cancer specific survival was 84,5%. Erectile function was preserved in the most of patients as postoperative IIEF-5 score within 12 months after surgery was > 12 in the 82.1%. About the urinary incontinence, 0.76% of the patients presented severe incontinence (continued and persistent loss of urine) and 7.0% were mildly incontinent (using up to one pad per day). Conclusions; eLRP has shown oncological and functional results comparable to other minimally invasive techniques and to open radical prostatectomy (ORP), with favorable perioperative outcomes than the open technique and a reduced complication rate.

Laparoscopic versus open radical retropubic prostatectomy: a case-control study at a single institution.

We retrospectively compared 50 patients treated with open retropubic prostatectomy (RRP) with 50 patients treated with laparoscopic extraperitoneal radical prostatectomy (LRP) at our institution, in the same time period, with a follow-up up to 7 years. We focused on operative data, complications, pathological outcome and mid-term outcome and follow-up in terms of oncological results. The same surgeons performed both operations. The 2 groups were similar with respect to mean patient age, mean prostate specific antigen value, median Gleason score. No previous transurethral resection of the prostate nor neoadjuvant treatment, had been undertaken in both groups of pts. Mean operating time was significantly shorter after open surgery (126 minutes, range 90-185 minutes) [p = 0.03] compared to the laparoscopic group (188 minutes, range 130-250) but it did not differ significantly from the last 20 laparoscopic procedures, in which the time of procedure was reduced to a mean of 155 minutes group (range 140-184 minutes) [p = 0.1]. Mean blood loss (1,150 versus 800 cc) and transfusion rates (55.7% versus 19.6%) in the 2 groups significantly favored the laparoscopic group. Number of lymphnodes dissected during the procedures favoured, but not significantly, the RRP group: for RRP a mean 11 lymphnodes right side, 13 left side (ranges 2-20 and 2-19 respectively), while for LRP a mean of 9 lymphnodes right side, 11 left side (ranges 2-15 and 2-13 respectively) were collected. The complication rate was almost the same in both groups, with no major adverse events nor deaths, (19.2% versus 14.7%) but the spectrum differed. The laparoscopic group had a higher incidence of fever (1.8% versus 3.2% respectively) and subcutaneous or scrotal emphysema, whereas more lymphoceles (6.9% versus 0%), wound infection (2.3% versus 0.5%), embolism/pneumonia (2.3% versus 0.5%) and anastomotic strictures (15.9% versus 4%) occurred after open surgery. Median catheter time was longer after open retropubic prostatectomy (22 versus 8.9 days, respectively) but the continence rates (intended as complete continence with no use of pads) were similar in both groups at 12 months (90.3% versus 91.7%). The rate of positive margins did not differ significantly in groups, and was in all cases very low (8.2% versus 7.0%), prostate specific antigen biochemical recurrence was equivalent (10% vs 10%). Data regarding postoperative sexual function favoured the laparoscopic group, even if no statistical significance was recorded (55% vs 67%). No statistical differences were observed in terms of oncological results, with a 24 months mean follow-up. Laparoscopic radical prostatectomy is technically demanding, with an initially longer operative time and learning curve. The overall outcome in our series favours the laparoscopic approach regarding catheterization time, recover of continence and impotence, hospital stay, transfusion rate. The open approach is favoured for the still shorter time necessitating for the procedure. Consequently, at our institution laparoscopic radical prostatectomy is becoming the method of choice.

Percutaneous treatment of staghorn stones: a retrospective case-control study with evaluation of single vs multiple access to the kidney.

Staghorn stones have been treated, up to 30 years ago, with open surgery. With the introduction of percutaneous procedure (PNL) and the use of shock wave lithotripsy (SWL) together with flexible instrumentation and Holmium Laser lithotripsy the indication for open surgery is actually very limited. On the other hand conservative treatment of staghorn calculi will result in a complete destruction of the kidney associated to a mortality rate up to 30%. The best results of surgical treatment have been obtained after anatrophic nephrolithotomy, with stone-free rates of 71 to 100%. In 1955 was first described the method of percutaneous nephrostomy insertion, and 20 years later was first reported on percutaneous nephrostolithotomy. Initially, only calculi no larger than the diameter of the nephrostomy tract were removed. Treatment of complex staghorn stones remained controversial because of the very high stone burden and it was also debated the choice between a single tract percutaneous approach, or a multiple tract approach in order to obtain a complete stone clearance. In our study we have compared the percutaneous approach with a single tract and the use of a flexible nephroscope in order to reach all the calices with the percutaneous approach with multiple accesses.

Bilateral same session ureteroscopy: safety and efficacy.

Actually ureteroscopy represents the therapy of choice for the treatment of ureteric stones. In the case of bilateral synchronous ureteric calculi the options are between a staged or a synchronous procedure; the last would potentially reduce costs and the need for a second anesthetic in comparison with a staged procedure. We reviewed our experience with bilateral same session ureteroscopy and compared with staged bilateral or unilateral procedure in the same series. The size and site of the stones were similar in all groups with a mean of 8.5 x 6.51 mm (15-7 x 10-5 mm). Symptoms were compared between the groups both before and after surgery, like painful urination, flank pain, urgency, nocturia, frequency, lower abdominal pain and urinary incontinence were assessed. A slight prevalence in the presence of hematuria was present in the bilateral same session URS group, probably due to the presence of the DJ stent. Urinary discomfort was more common in this group without reaching statistical significance (p>0.05). In no case differences between groups were statistically significant. No statistically significant differences were reported between the groups regarding postoperative pain (p>0.5). In our series, bilateral synchronous ureteroscopy is a safe procedure, with high stone free rate even compared with staged bilateral and monolateral treatment. It has the advantage of saving multiple procedures and the need of a second anesthesia and hospitalization. It can be performed safely with minimal risks. The positioning of a DJ stent at the end of the procedure adds little time, preventing post-operative complications with little discomfort for the patient.